Nutrim® and Cholesterol

Study: Oat-derived ß-Glucan Significantly Improves HDLC and Diminishes LDLC and Non-HDL Cholesterol in Overweight Individuals with Mild Hypercholestrolemia
Authors: Reyna-Villasmil N, Bermúdez-Pirela V, Mengual-Moreno E, Arias N, Cano-Ponce C, Leal-Gonzalez E, Souki A, Inglett GE, Israili ZH, Hernández-Hernández R, Valasco M, Arraiz N.
Publication:  Am J Ther. 2007 Mar-Apr;14(2):203-12.
Summary:  38 overweight men with high cholesterol were split equally placed on an AHA step II diet with either 6g of fiber from wheat bread or 6g ß-glucan from Nutrim® baked into bread. They were also instructed to walk for 60 minutes a day. At the end of 8 weeks the subjects had blood draws that were then compared to their initial blood work. The Nutrim® group saw significant improvement in lipid profile and body weight without any adverse effects.

Oat ß-glucans and Cholesterol


Quote from Study: Oat ß-glucan mediates an increase in bile acid secretion, which most probably explains the effect of oat fiber in lowering cholesterol

Study:  Oat ß-Glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol execretion in ileostomy subjects
Authors:  A got Lia, Goran Hallmans, Ann-Sofie Sandberg, Birgitta Sundberg, Per Aman, and Henrik Andersson
Publication: Am J Clin Nutr. 1995;62: 1245-51.
Summary:  10 ileostomy patients were fed 4 diets, each for 2 days. The 4 diets included 4 different types of bread: oat bran, oat bran with ß-glucanase (an enzyme that breaks down ß-glucans), barley, and wheat. Feeding oat bran bread resulted in a 53% higher bile acid secretion compared to oat bran bread with ß-glucanase. Oat bran bread also resulted in significantly more excretion of bile acids compared with barley and wheat breads.

Quote from Study: …increased viscosity of the contents of the small intestine may contribute to the low glycemic index and hypocholesterolaemic effects of oats in man

Study:  Effects of oat gum on the physical properties of the gastrointestinal contents and on the uptake of D-galactose and cholesterol by rat small intestine in vitro
Authors:  E. K. Lund, J. M. Gee, J. C. Brown, P. J. Wood and I. T. Johnson
Publication:  British Journal of Nutrition (1989), 62 : pp 91-101
Summary:  Wister rats were fed 3 meals of either a control diet, a diet containing oat gum (ß-glucan), or finely ground rolled oats. The oat meals increased intestinal viscosity and wet to dry ratio of digestive tract contents. Cholesterol uptake and sugar was inhibited by oat gum.

Quote from Study: A reduced cholesterol absorption contributes to the cholesterol lowering effect of ß-glucans without affecting plasma concentrations of lipid soluble antioxidants.

Study:  ß-Glucan incorporated into a fruit drink effectively lowers serum LDL cholesterol concentrations
Authors:  Elke Naumann, Angelina B van Rees, Gunilla O ̈ nning, Rickard O ̈ ste, Markus Wydra, and Ronald P Mensink
Publication:  Am J Clin Nutr 2006;83:601–5.
Summary: 22 participants consumed 5g of rice starch and 25 participants consumed 5 g of ß-glucans from oats for 3 weeks. The ß-glucan group lowered total and LDL cholesterol. Cholesterol absorption was reduced without reducing absorption of fat soluble antioxidants.

Highlights: Consumption of oat cereal was associated with a reduction in plasma levels of both total cholesterol and LDL-c.

Study:  Cholesterol lowering benefits of oat-containing cereal in Hispanic Americans
Authors:  Karmally W, Montez MG, Palmas W, Martinez W, Branstetter A, Ramakrishnan R, Holleran SF, Haffner SM, Ginsberg HN.
Publication:  J Am Diet Assoc. 2005 Jun;105(6):967-70.
Summary:  152 men and women were randomly assigned to eat 3g ß- glucans from oat cereal or corn cereal. The ß-glucan group significantly lowered total and LDL cholesterol while corn slightly raised cholesterol.

Quote from Study: …oat bran, within a practical range of intake significantly reduces total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B… independant of covariables such as physical activity or caloric and fat restriction in the diet.

Study:  Effects of oat bran enriched diet on the atherogenic lipid profile in patients with an increased coronary heart disease risk. A controlled randomized lifestyle intervention study
Authors:  Berg A, König D, Deibert P, Grathwohl D, Berg A, Baumstark MW, Franz IW.
Publication:  Ann Nutr Metab. 2003;47(6):306-11.
Summary:  99 patients received a fat modified diet with caloric restriction, exercise, and health education along with 35-50g of oat bran per day, while 136 men received the same diet and lifestyle program without oat bran. 53 men served as controls. A significant reduction was seen in the oat bran group for total (-67.7 mg/dl) and LDL cholesterol(-56.3mg/dl), as well as a reduction in apolipoprotein(-42.4mg/dl).

Quote from Study: The main component of the soluble fiber of oats, ß-glucan, significantly reduced the total and LDL cholesterol levels of hypercholesterolemic adults…

Study:  Oat ß-glucan reduces blood cholesterol concentrations in hypercholesterolemic subjects
Authors:  Braaten JT, Wood PJ, Scott FW, Wolynetz MS, Lowe MK, Bradley-White P, Collins MW.
Publication:  Eur J Clin Nutr. 1994 Jul;48(7):465-74.
Summary:  A crossover study was carried out with 19 Men and women who were fed either 2.9g ß-glucan twice per day or a placebo for 4 weeks. The placebo made no significant changes in cholesterol while the ß-glucan reduced total and LDL cholesterol.

Quote from Study: Thus, a practical dose of β-glucan can significantly lower serum lipids in a high-risk population and may improve colon health.

Study:  Concentrated oat ß-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
Authors:  Katie M Queenan, Maria L Stewart, Kristen N Smith, William Thomas, R Gary Fulcher and Joanne L Slavin
Publication:  Nutr J. 2007 Mar 26;6:6.
Summary:  75 men and women were randomly assigned to either 6g/day of oat ß-glucan or 6 grams/day of dextrose for 6 weeks.  The ß-glucan group saw significant decreases in total and LDL cholesterol compared with the placebo group.

Quote from Report: Therapeutic lifestyle changes are the foundation of clinical primary prevention.

Report:  Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)


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