Oat ß-glucan Research- Cholesterol

  • Oat ß-Glucan Study Highlight:Oat ß- glucan mediates an increase in bile acid secretion, which most probably explains the effect of oat fiber in lowering cholesterol

    Study:  Oat ß-Glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol execretion in ileostomy subjects
    Authors:  A got Lia, Goran Hallmans, Ann-Sofie Sandberg, Birgitta Sundberg, Per Aman, and Henrik Andersson
    Publication:   Am J Clin Nutr. 1995;62: 1245-51.
    Summary:  10 ileostomy patients were fed 4 diets, each for 2 days.  The 4 diets included 4 different types of bread: oat bran, oat bran with ß-glucanase (an enzyme that breaks down ß- glucans), barley, and wheat.  Feeding oat bran bread resulted in a 53% higher bile acid secretion compared to oat bran bread with ß-glucanase.  Oat bran bread also resulted in significantly more excretion of bile acids compared with barley and wheat breads.
    Link:  http://www.ajcn.org/cgi/reprint/62/6/1245

  • Nutrim Study Highlight: LDLc ↓27.3%, HDLc ↑27.8%, LDLc:HDLc ↓42.1% & weight ↓7.5%

    Study: Oat-derived ß-Glucan Significantly Improves HDLC and Diminishes LDLC and Non-HDL Cholesterol in Overweight Individuals with Mild Hypercholestrolemia
    Authors: Reyna-Villasmil N, Bermúdez-Pirela V, Mengual-Moreno E, Arias N, Cano-Ponce C, Leal-Gonzalez E, Souki A, Inglett GE, Israili ZH, Hernández-Hernández R, Valasco M, Arraiz
    Publication:  Am J Ther. 2007 Mar-Apr;14(2):203-12.
    Summary:  38 overweight men with high cholesterol were split equally placed on an AHA step II diet with either 6g of fiber from wheat bread or 6g ß- glucan from Nutrim® baked into bread.  They were also instructed to walk for 60 minutes a day.  At the end of 8 weeks the subjects had blood draws that were then compared to their initial blood work.  The Nutrim® group saw significant improvement in lipid profile and body weight without any adverse effects.
    LDLc ↓27.3%                       |       HDLc ↑27.8%               |        Non-HDLc ↓24.5%
    triglycerides ↓4.2%           |       Body weight ↓7.5%   |        VLDL ↓4.9%
    total cholesterol ↓15.9% |       LDLc:HDLc  ↓42.1%  |       fasting glucose ↓5.9%
    Link:  http://www.ncbi.nlm.nih.gov/pubmed/17414591

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